Installing Data Processing Software on OS X
From OS X Scientific Computing
Mosflm Home Page
You can get information on mosflm as well as both source code and pre-compiled binaries from that page.
In general, it is best to use what is comes with CCP4.
There may also be a fink package for mosflm that may have a more current version (usually this is true only when the release of CCP4 is near the end of the cycle).
Clink on the above link to get to my notes.
There is also a fink package called imosflm that installs various tcltk extensions required for the new gui. It uses whatever mosflm is at the head of the path. It uses an X-windows version of tk.
You can also install an aqua-based tcltk (the one that comes by default is not adequate) as described on the mosflm iMosflm page
There are versions of XDS for OS X available from the XDS site.
There is an OS X version of HKL2000. I have no experience with it.