Complete List of Publications

  1. Sara M. O'Rourke, William Estell and William G. Scott Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity. Journal of Molecular Biology 427: 2340–2347 (2015).

  2. Alastair C. Fyfe, Pete W. Dunten, Monika M. Martick and William G. Scott Structural Variations and Solvent Structure of r(UGGGGU) Quadruplexes Stabilized by Sr2+ Ions Journal of Molecular Biology 427: 2205-2219 (2015).

  3. William G. Scott How fluorescent RNA gets its glow. Nature 513: 42-43 (2014).

  4. William G. Scott, Abraham Szöke, Josh Blaustein, Sara M. O'Rourke and Michael P. Robertson. RNA Catalysis, Thermodynamics and the Origin of Life. Life 4: 131-141 (2014). doi:10.3390/life4020131

  5. Schultz, E. P., Vazquez, E., and Scott, W. G. Structural and catalytic effects of an invariant purine substitution in the hammerhead ribozyme: implications for the mechanism of acid - base catalysis. Acta Crystallographica Section D: Biological Crystallography D70: 2256-2263 (2014)

  6. Michael Anderson, Eric P. Schultz, Monika Martick and William G. Scott Active-Site Monovalent Cations Revealed in a 1.55 Å Resolution Hammerhead Ribozyme Structure Journal of Molecular Biology 425: 3790–3798 (2013).

  7. William G. Scott, Lucas H. Horan, and Monika Martick The Hammerhead Ribozyme: Structure, Catalysis,and Gene Regulation. Progress in Molecular Biology and Translational Science: Catalytic RNA, G. A. Soukup, ed. 120: 1-24 (2013). ISBN: 978-0-12-381286-5

  8. Giambasu GM, Lee TS, Scott WG, York DM. Mapping L1 ligase ribozyme conformational switch. Journal of Molecular Biology 423:106-122 (2012)

  9. Scott WG. Challenges and surprises that arise with nucleic acids during model building and refinement. Acta Crystallogr D Biol Crystallogr. 68: 441-445 (2012)

  10. Adrian R. Ferré-D'Amaré and William G. Scott, Small Self-cleaving Ribozymes, RNA World, 4th ed., Cold Spring Harb Perspect Biol. 2010 Sep 15. [Epub ahead of print]

  11. William G. Scott, What can the New Hammerhead Ribozyme Structures Teach us About Design? V.A. Erdmann and J. Barciszewski (eds.), RNA Technologies and Their Applications, 305 RNA Technologies, DOI 10.1007/978-3-642-12168-5_14, # Springer-Verlag Berlin Heidelberg (2010)

  12. Robertson MP, Chi YI, Scott WG. Solving novel RNA structures using only secondary structural fragments. Methods. (2010) Jun 9.

  13. Emsley P, Lohkamp B, Scott WG, Cowtan K. Features and development of Coot. Acta Crystallogr D 66:486-501 (2010).

  14. Giambasu GM, Lee TS, Sosa CP, Robertson MP, Scott WG, York DM. Identification of dynamical hinge points of the L1 ligase molecular switch. RNA 16:769-80 (2010).

  15. William G. Scott, Monika Martick and Young-In Chi, Structure and function of regulatory RNA elements: Ribozymes that regulate gene expression Biochimica et Biophysica Acta 1789: 634-641 (2009).

  16. Sara M. O'Rourke, Becky Schweighardt, William G. Scott, Terri Wrin, Dora P. A. J. Fonseca, Faruk Sinangil, and Phillip W. Berman, Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies. J. Virology 83: 7728-7738 (2009).

  17. Tai-Sung Lee, George M. Giambasu, Carlos P. Sosa, Monika Martick, William G. Scott and Darrin M. York, Threshold Occupancy and Specific Cation Binding Modes in the Hammerhead Ribozyme Active Site are Required for Active Conformation J. Mol. Biol. 388: 195-206 (2009).

  18. Andrei Korostelev, Haruichi Asahara, Laura Lancaster, Martin Laurberg, Alexander Hirschi, Jianyu Zhua, Sergei Trakhanova, William G. Scott, and Harry F. Noller, Crystal structure of a translation termination complex formed with release factor RF PNAS 105: 19684-19689 (2008).

  19. Jennifer Daub, Paul P. Gardner, John Tate, Daniel Ramsköld, Magnus Manske, William G. Scott, Zasha Weinberg, Sam Griffiths-Jones, and Alex Bateman, The RNA WikiProject: Community annotation of RNA families. RNA14: 1-3 (2008).

  20. Young-In Chi, Monika Martick, Rosalind Kim, William G. Scott and Sung-Hou Kim, Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis. PLoS Biology 6(9): e234. (2008).

  21. Monika Martick, Lucas H. Horan, Harry F. Noller and William G. Scott, A Discontinuous Hammerhead Ribozyme Embedded in a Mammalian mRNA. Nature 454: 899-902 (2008).

  22. Daniel J. Koslover, Anastasia J. Callaghan, Maria J. Marcaida, Elspeth F. Garman, Monika Martick, William G. Scott, and Ben F. Luisi, The Crystal Structure of the Escherichia coli RNase E Apoprotein and a Mechanism for RNA Degradation. Structure 16: 1238-1244 (2008).

  23. Michael P. Robertson and William G. Scott, A general method for phasing novel complex RNA crystal structures without heavy- atom derivatives. Acta Cryst D 64: 738-744 (2008).

  24. Monika Martick, Tai-Sung Lee, Darrin M. York and William G. Scott, Solvent Structure and Hammerhead Ribozyme Catalysis Chemistry and Biology 15: 332-342 (2008).

  25. Tai-Sung Lee, Carlos Silva Lopez, George M. Giambau, Monika Martick, William G. Scott, and Darrin M. York, Role of Mg2+ in Hammerhead Ribozyme Catalysis from Molecular Simulation, J. Am. Chem. Soc. 130: 3053-3064 (2008).

  26. William G. Scott, "Hammerhead Ribozyme Crystal Structures and Catalysis", Chapter 4 of Ribozymes and RNA Catalysis, edited by David Lilley and Fritz Eckstein. (Royal Society of Chemistry Publ., 2008). pp.48-63.

  27. Michael P. Robertson and William G. Scott, Designer Enzymes Nature 448: 757-758 (2007).

  28. William G. Scott, Ribozymes Current Opinion in Structural Biology 17: 727-735 (2007).

  29. William G. Scott, Morphing the minimal and full-length hammerhead ribozymes: implications for the cleavage mechanism Biological Chemistry 388: 727-735 (2007).

  30. Michael P. Robertson and William G. Scott, The Structural Basis of Ribozyme-Catalyzed RNA Assembly Science 315: 1549-1553 (2007).

  31. Tai-Sung Lee, Carlos Silva-Lopez, Monika Martick, William G. Scott, and Darrin M. York Insight into the Role of Mg2+ in Hammerhead Ribozyme Catalysis from X-ray Crystallography and Molecular Dynamics Simulation J. Chem. Theory Comput. 3: 325-327 (2007).

  32. Monika Martick and William G. Scott, Tertiary Contacts Distant from the Active Site Prime a Ribozyme for Catalysis Cell 126: 309-320 (2006).

  33. Anastasia J. Callaghan, Maria Jose Marcaida, Jonathan A. Stead, Kenneth J. McDowall, William G. Scott and Ben F. Luisi, Structure of E. coli RNase E catalytic domain and its implications for RNA turnover and processing. Nature 437: 1187-1191 (2005).    

  34. M. P. Robertson, H. Igel, R. Baertsch, D. Haussler, M. Ares, Jr., and W. G. Scott The Structure of a Rigorously Conserved RNA Element within the SARS Virus Genome  Public Library of Science: Biology 3(1): e5. (2005).

  35. A. Szöke, W. G. Scott, J. Hajdu Catalysis, evolution and life.  FEBS Letters 553: 18-20 (2003).

  36. C. M. Dunham, J. B. Murray and W. G. Scott, A Helical Twist-induced Conformational Switch Activates Cleavage in the Hammerhead Ribozyme.  Journal of Molecular Biology 332: 327-336 (2003).

  37. C. M. Dunham, E. M. Dioum, J. R. Tuckerman, Gonzalo Gonzalez, W. G. Scott and M.-A. Gilles-Gonzalez A Distal Arginine in Oxygen-Sensing Heme-PAS Domains is Essential to Ligand Binding, Signal Transduction and Structure.  Biochemistry 42: 7701-7708 (2003).

  38. W. G. Scott, Visualizing the structure and mechanism of a small nucleolytic ribozyme.  Methods 28: 302-306 (2002).

  39. C. S. Burns, et. al, Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein.  Biochemistry 41, 3991-4001, (2002).

  40. J. B. Murray, C. M. Dunham and W. G. Scott, A pH-Dependent Conformational Change, Rather than the Chemical Step, Appears to be Rate-Limiting in the Hammerhead Ribozyme Cleavage Reaction , Journal of Molecular Biology 315, 121-130 (2002).

  41. W. G. Scott, Ribozyme Catalysis via Orbital Steering, Journal of Molecular Biology 311, 989-999 (2001).

  42. J. B. Murray, H. Szöke and A. Szöke and W. G. Scott, Capture and Visualization of a Catalytic RNA Enzyme-Product Complex Using Crystal Lattice Trapping and X-ray Holographic Reconstruction. Molecular Cell 5, 279-287 (2000).

  43. J. B. Murray and W. G. Scott, Does a Single Metal Ion Bridge the A-9 and Scissile Phosphates of the Hammerhead Ribozyme Structure? Journal of Molecular Biology296, 33-41 (2000). Erratum .

  44. W. G. Scott and J. B. Murray, Conventional and Time-Resolved Ribozyme X-ray Crystallography. Methods in Enzymology 317, 180-198 (2000).

  45. L. Jovine, T. Hainz, C. Oubridge, W. G. Scott, J. Li, T. K. Sixma, A. Wonacott, T. Skarzynski & K. Nagai, Crystal Structure of the ffh and EF-G binding sites in the conserved domain IV of E. coli 4.5S RNA. Structure 15, 527-540 (2000).

  46. W. G. Scott, RNA Structure and Catalysis, Quarterly Reviews of Biophysics 32, 241-284 (1999) [published in 2000].

  47. W. G. Scott, RNA Structure, Metal Ions and Catalysis, Current Opinion in Chemical Biology 3, 705-709 (2000).

  48. J. K Robinson, W. G. Scott, K. L. Rowlen & J. W. Birks, Derivitization of thymine and thymine photodimers with 4-bromomethyl-7-methoxycoumarin for fluorescence detection in high-performance liquid chromatography. J. Chromatography B. Biomed. Sci. Appl.731, 179-186 (2000).

  49. J. B. Murray, D. P. Terwey, L. Maloney, A. Karpeisky, N. Usman, L. Beigelman and W. G. Scott, The Structural Basis of Hammerhead Ribozyme Self-Cleavage. Cell 92, 665-673 (1998).

  50. J. B. Murray, A. Seyhan, N. Walter, J. M. Burke and W. G. Scott, The Hammerhead, Hairpin and VS Ribozymes Do Not Require Divalent Metal Ions for Folding and Catalysis, Chemistry and Biology 5: 587-595 (1998).

  51. A. L. Feig, W. G. Scott and O. C. Uhlenbeck, Inhibition of the Hammerhead Ribozyme Cleavage Reaction by Site-Specific Binding of Tb(III). Science 279, 81-84 (1998).

  52. W. G. Scott, RNA Catalysis, Curr Opin Struct Biol. 8:720-6 (1998).

  53. T. Hermann, P. Auffinger, W. G. Scott and E. Westhof, Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme. Nucleic Acids Research 25, 3421-7 (1997).

  54. W. G. Scott+, J. B. Murray, B. L. Stoddard and A. Klug, Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme. Science 274, 2065-2069 (1996). [ +corresp. author]

  55. W. G. Scott and A. Klug, Ribozymes: Structure and Function in RNA Catalytic Cleavage. Trends in Biochemical Sciences , 21, 220-223 (1996).

  56. W. G. Scott, "Crystallographic Analyses of Chemically Synthesized Modified Hammerhead RNA Sequences as a General Approach Toward Understanding Ribozyme Structure and Function." in Methods in Molecular Biology, Vol 74: Ribozyme Protocols, Chapter 41. (P. Turner, Ed. Humana Press, USA) (1996).

  57. W. G. Scott, Molecular palaeontology: Understanding catalytic mechanisms in the RNA world by excavating clues from a ribozyme three-dimensional structure. Biochem. Soc. Trans.24, 604-608 (1996).

  58. J. M. Bolduc*, D. H. Dyer*, W. G. Scott*, P. Singer, R. M. Sweet, D. E. Koshland, Jr. and B. L. Stoddard. "Mutagenesis and Laue Structures of Enzyme Intermediates: Isocitrate Dehydrogenase," Science 268, 1312-1318 (1995). [*equal contributors]

  59. W. G. Scott, J. T. Finch and A. Klug, The crystal structure of Structure of an All-RNA Hammerhead Ribozyme, Nucleic Acids Symposium Series 34, 214-216 (1995).

  60. W. G. Scott, John T. Finch and Aaron Klug, Three-Dimensional Structure of an all-RNA Hammerhead Ribozyme: A proposed mechanism for RNA catalytic cleavage, Cell 81, 991-1002 (1995).

  61. W. G. Scott, John T. Finch, Richard Grenfell, Jan Fogg, Terry Smith, Michael J. Gait and Aaron Klug, Rapid Crystallization of Hammerhead RNAs Using a Double-Screening Approach, Journal of Molecular Biology 250, 327-332(1995).

  62. W. G. Scott and B. L. Stoddard, Transmembrane Signalling and the Aspartate Receptor. Structure 2, 877-887 (1994).

  63. W. G. Scott, M. V. Milburn, G. G. Privé, D. L. Milligan, J. Yeh, D. E. Koshland, Jr., and S.-H. Kim. Refined Structures of the Ligand-Binding Domain of the Aspartate Receptor from Salmonella typhimurium. Journal of Molecular Biology232, 555-573 (1993).

  64. S.-H. Kim, G. G. Prive, J. Yeh, W. G. Scott & M. V. Milburn, A model for transmembrane signalling in a bacterial chemotaxis receptor. Cold Spring Harbor Symposium on Quantitative Biology 57, 17-24 (1992).

  65. M. V. Milburn, G. G. Privé, D. L. Milligan, W. G. Scott, J. Yeh, J. Jancarik, D. E. Koshland, Jr., and S.-H. Kim, Three-Dimensional Structures of the Ligand-Binding Domain of the Bacterial Aspartate Receptor With and Without a Ligand. Science 254, 1342-1348 (1991).

  66. J. Jancarik, W. G. Scott, D. L. Milligan, D. E. Koshland Jr and Kim SH.  Crystallization and preliminary X-ray diffraction study of the ligand-binding domain of the bacterial chemotaxis-mediating aspartate receptor of Salmonella typhimurium. Journal of Molecular Biology 221: 31-34 (1991).

  67. M. Boni-Schnetzler, W. Scott, S.M. Waugh, E. DiBella and P.F. Pilch, The insulin receptor. Structural basis for high affinity ligand binding. J. Biol. Chem.262: 8395-401 (1987).