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Understanding the relationship between
the three-dimensional structure of a biological macromolecule and
its function within an organism is one of the most important and
exciting open problems residing at the interface between chemistry
and biology today. Employing techniques from molecular biology as
well as biophysical chemistry (primarily conventional and
time-resolved X-ray crystallography), our principal objectives are
to understand how RNA can have enzymatic activity, how proteins and
drugs interact with RNA, and also how protein enzymes and receptors
function. Within that context, we also encourage members of our
laboratory to develop their own projects. The nature of our
research is fundamentally collaborative, (we collaborate with other
research groups in the chemistry and biology departments and
elsewhere), and we aim to conduct it in an open, supportive and
nonhierarchical environment, and to have fun doing so.
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